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Its a fundamental difference in strategy

By blocking NNMT activity, it increases critical cellular metabolites (SAM, NAD) that drive downstream increases in energy expenditure and metabolic health 1-4

Due to its versatility, it has become a key compound in the realm of regenerative medicine

This is why B12 deficiency gets mistaken for burnout, depression, or just "getting older." The symptoms overlap

their dysfunction leads to energy deficits that manifest as fatigue and slowed healing