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Second, enrolled populations differed substantially with respect to baseline cerebrovascular risk and clinical context (recent ACS in ELIXA vs chronic stable atherosclerotic disease vs mixed primary prevention in REWIND), which can alter stroke subtype distribution and the time course over which vascular risk modification translates into event reduction [44,46]

We used FineGray sub-distribution hazard model analyses adjusted for sex and age to assess the association of sociodemographic variables, comorbidities and co-medications (defined in ESM Table 2) with the risk of treatment discontinuation

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If the patient is anemic, then a simple transfusion of red blood cells will immediately improve the total hemoglobin level and the functional hemoglobin level