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Improved mitochondrial function underlies the protective effect of pirfenidone against tubulointerstitial fibrosis in 5/6 nephrectomized rats

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Participants were randomized 1:1:1 to retatrutide 9 mg weekly, retatrutide 12 mg weekly, or placebo, and treated for 68 weeks

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The structural features can be grouped into two categories: non-standard amino acid substitutions (Orn11, -methyl-Phe15, N2-methyl-Asn22) and other structural modifications (N-terminal -Glu, Cys2Cys7 methylene thioacetal bridge, Lys26 lipid side chain, C-terminal amide)