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With projections like this, its likely these are not temporary spikes in spend but rather becoming a sustained and growing financial burden

What the Clinical Data Actually Shows The most definitive comparison comes from the SURMOUNT-5 trial, a direct head-to-head study published in the New England Journal of Medicine comparing tirzepatide 10 mg and 15 mg against semaglutide 2.4 mg in adults with obesity but without diabetes

Maternal diet rich in omega-6 polyunsaturated fatty acids during gestation and lactation produces autistic-like sociability deficits in adult offspring

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REDEFINE 11, initiated June 2025, tests extended treatment duration

Although our primary analyses focused on AOM tirzepatide and AOM semaglutide, we extracted dispense data for all GLP-1 RAs to examine overall treatment transitions and identify which therapies patients switched to