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People with certain medical conditions, including a history of pancreatitis or thyroid cancer, may not be good candidates, and should speak with their doctor to decide what management strategies are right for them

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Evidence from the SURPASS-4 trial suggests that weight loss and improved blood sugar control from tirzepatide may help slow CKD progression in people with diabetic kidney disease

Future research should focus on developing direct ERAD-targeting therapies and optimizing existing approaches to translate these findings into clinical applications

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