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You become pregnant or are trying to conceive while taking a GLP-1
More serious considerations include risk of pancreatitis, gallbladder problems, kidney injury (often related to dehydration from gastrointestinal symptoms), and rare cases of medullary thyroid cancer (these medications carry a black box warning for patients with personal or family history of MTC or MEN2 syndrome)
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Doses of vitamin B12 exceeding 10 mcg daily may produce a hematologic response in patients who have a folate deficiency