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4 At three months, 45% of those taking Pycnogenol had improvements in occasional ringing in the ears compared with 23% in the control group

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Secondly, the redox status of the cell affects many of the enzymes in one-carbon metabolism including MATI, MATIII, MS, BHMT, as well as CBS and GCS in the transsulfuration pathway, and therefore one cannot evaluate GSH metabolism without including the methionine and folate cycles