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Key Point: Weight loss medications, combined with a healthy lifestyle, can lead to significant weight loss and reduce risks associated with obesity, such as heart disease and type 2 diabetes

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Treatment of Otsuka Long Evans Tokushima Fatty (OLETF) rats, an obese animal model of type 2 diabetes, with the PPAR agonist fenofibrate reduced the decline in beta cell mass and prevented the development of diabetes [23]

It also appears to help preserve lean muscle mass during weight loss, a critical advantage that most weight loss medications lack