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In addition to reducing liver-related complications, NAFLD management should reduce macrovascular outcomes [27]

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Usually, the greater the starting body weight and the greater the calorie deficit, the greater the weight loss at least initially, says Rothberg

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The primary pathway involves amplification of glucose-triggered insulin production by pancreatic beta cells, which enhances adipose tissue nutrient uptake and reduces circulating free fatty acid flux to the liver [28]

Again, the dose gap is orders of magnitude