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Low B12 levels have been linked to mood swings, irritability, and even symptoms of depression

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Patients with features such as rapid progression, significant asymmetry, predominant motor symptoms, severe autonomic dysfunction, or unexplained weight loss should receive expedited evaluation, as these may indicate alternative or additional diagnoses requiring different management approaches

Cryotherapy has been used in patients with Barretts esophagus with high-grade dysplasia and persistent low-grade dysplasia as well as early stage esophageal cancer that is not amenable to standard therapies, including surgery, chemotherapy and radiation therapy

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The 2023 international PCOS guideline notes that inositol shouldn't be used as a stand-alone fertility treatment, but it can support metabolic and ovulatory function alongside medical care