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And it influences the hypothalamic-pituitary-adrenal axis, which connects immune regulation to stress response, an important consideration given that psychological stress is a known trigger for lupus flares

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Glutamine Metabolism Pathways TCA Cycle and IDH2 In the TCA cycle, glutamine-derived -ketoglutarate converts to isocitrate and citrate

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In the SURPASS-2 trial, thyroid adverse events occurred in fewer than 1% of participants, and nodule formation was not statistically different between tirzepatide and control groups