Triple agonists (e.g., retatrutide: GLP-1/GIP/glucagon receptor agonism) are under active investigation and may further amplify cardiometabolic benefits [108]
pseudomallei (43)
Clinical Pharmacology (Elsevier) does not flag it as a discrete interaction
In Vivo Assessment of Drug Interactions Effects of Sitagliptin on Other Drugs In clinical studies, sitagliptin did not meaningfully alter the pharmacokinetics of metformin, glyburide, simvastatin, rosiglitazone, digoxin, warfarin, or an oral contraceptive (ethinyl estradiol and norethindrone) (Table 4), providing in vivo evidence of a low propensity for causing drug interactions with substrates of CYP3A4, CYP2C8, CYP2C9, P-gp, and organic cationic transporter (OCT)
Last Published 06.01.2026 Effective Date: 06.01.2026 This policy addresses the use of Cosentyx (secukinumab) for the treatment of psoriatic arthritis (PsA), ankylosing spondylitis (AS), and non-radiographic axial spondyloarthritis (nr-axSpA)
doi: 10.1016/j.ajo.2024.10.016 135