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Conversely, BCAT1 expression is upregulated in certain tumors, potentially promoting tumor growth through glutamate generation, provision of nitrogen sources for nucleotide synthesis, and mTORC1 signaling activation (60)

Loss-of-function polymorphisms and a rare missense mutation in human CAMKK2 are associated with bipolar disorder, and genetic deletion of Camkk2 in mice causes bipolar-like behaviours similar to those in patients

GLP-1 receptor agonists have been shown to improve diabetes, reduce cardiovascular events, and cause life-changing weight loss

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Life-span extension in mice by preweaning food restriction and by methionine restriction in middle age