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FDA officials said at the time they were concerned about the impact of widening approval for a drug that has known serious side effects such as liver damage

Lauri Billingsley and Mari Tietze of the University of Texas at Arlington explain

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142 In addition, GLP-1 RA upregulated neurotrophic tyrosine kinase receptor type 2 and mTOR genes in the hippocampus of high-fat-fed mice, which are involved in regulating synaptic plasticity and LTP