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POTENTIAL MECHANISMS UNDERLYING THE DECLINE IN GH SECRETION WITH AGE Three hypothalamic factors regulate GH secretion: somatostatin (Somatotropin Release-Inhibiting Factor, SRIF), growth hormone-releasing hormone (GHRH), and ghrelin (11) (Figure 2)

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This mechanism is crucial in understanding how these peptides influence cellular recovery, skin regeneration, and overall tissue health at a molecular level

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The molecular compound nitric oxide aids in transmitting signals to the cells allowing for intercellular communication