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Promising evidence of the efficacy of pioglitazone among NAFLD diabetic patients has been demonstrated in a RCT of pioglitazone versus placebo involving 55 subjects, which showed a significant histological improvement of steatosis, inflammation and ballooning, and reduction in liver fat content (assessed by magnetic resonance spectroscopy) after treatment [41]
Quality control metrics and metabolite detection for this sample were comparable to those of other samples, supporting the interpretation that this observation reflects inter-individual metabolic variability within the ASD cohort
As noted earlier, more of the GLP-1 users showed improvement, and consequently more of the non-user group showed worsened disease (46% vs 29%)
We have issued guidance to prescribers and pharmacists that medicines which are solely licensed to treat type 2 diabetes such as Ozempic should not be routinely prescribed for weight loss
Raccah, R.N
