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However, while early findings are promising, more robust clinical research is needed to confirm these effects.

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Figure 8 Abnormal coagulation: the role of microclots and inflammagens in circulation that cause pathological clotting It has been hypothesised that hypercoagulation plays a significant role in ME/CFS (349351), but there are still discrepancies between studies (352)

When conjugated to nanoparticles, apolipoproteins can significantly improve brain uptake through LDL receptor-mediated transcytosis

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The biomimetic nanodelivery systems (BNDSs) were developed more recently and exhibit the advantages of inherent natural biocompatibility, low immunogenicity, and promising potential due to the fact that they are made directly from cell membranes (normal or diseased cells) or by coating nanoparticle surface with cell membranes [11]