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J Med Chem 58:73707380 Gotfredsen CF, Molck AM, Thorup I et al (2014) The human GLP-1 analogs liraglutide and semaglutide: absence of histopathological effects on the pancreas in nonhuman primates

doi: 10.1073/pnas.89.18.8641

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In parallel, there is growing focus on small molecule GLP-1R agonists , which have the potential to be administered orally, produced more cost-effectively, and offer improved stability and pharmacokinetic profiles