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The ratio of membrane versus cytosolic IGF-1R localization in the untreated panel indicates cytosolic retention of hyposialylated IGF-1R in GNE knockdown cells but not in V603L GNE mutant cells

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Every post-weight-loss patient starts these as soon as surgical planning begins, regardless of what the bloods eventually show

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Consequently, its dysfunctionmanifesting in prevalent conditions like metabolic dysfunction-associated steatotic liver disease (MASLD), alcohol-related liver disease (ALD), and drug-induced liver injury (DILI)poses a severe and growing global health challenge

doi:10.1038/s41598-020-75334-9