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Anxiety, Behavioral Disinhibition and Stress Lurcher mice show abnormal behavior in anxiogenic conditions (Table 3)

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The CXCR4 receptor appears to be critically involved in many of these effects, particularly in regulating autophagy, IGF-1 abundance, Akt phosphorylation, and oxidative stress, as AMD3100 reversed these protective actions

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It is also involved in the removal of toxic compounds from cells, preventing their accumulation

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