Kraemer WJ, Volek JS, French DN, Rubin MR, Sharman MJ, Gmez AL, Ratamess NA, Newton RU, Jemiolo B, Craig BW, Hkkinen K
You just doubled your dose
Thus, since several mutations affecting the functional domains of p62 have been identified in patients with ALS and frontotemporal dementia, it has been demonstrated that p62 variants exhibit reduced KEAP1-binding, preventing NRF2 from entering the nucleus and promoting protective genes, and predisposing the cell death upon exposure to ROS [250, 251]
10.1074/jbc.M310991200
These include irritation, inflammation, and high eye pressure
Westerterp M, Gautier EL, Ganda A, Molusky MM, Wang W, Fotakis P, Wang N, Randolph GJ, DAgati VD, Yvan-Charvet L, Tall AR (2017) Cholesterol Accumulation in dendritic cells links the Inflammasome to Acquired Immunity