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The parabrachial nucleus elicits a vigorous corticosterone feedback response to the pro-inflammatory cytokine IL-1

Badshah I, Qazi NG, Ali F, Minhas AM, Alvi AM, Kandeel M, et al

Interestingly, nitric oxide inhibits mitochondrial respiration by reacting with either the reduced or the oxidized binuclear site of cytochrome c oxidase, leading to ATP depletion

The most commonly reported adverse effects in the trial were gastrointestinal in nature including nausea, diarrhoea, vomiting, and constipation which is consistent with the broader GLP-1 receptor agonist class

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