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Pavone C, Napoli G, Caruana G et al: Safety and tolerability of local treatment with iloprost, a prostacyclin analogue, in patients with Peyronie's disease: a phase I study

J Pharmacol Exp Ther 282(3):15331540 Thompson RA, Isin EM, Li Y, Weidolf L, Page K, Wilson I, Swallow S, Middleton B, Stahl S, Foster AJ, Dolgos H, Weaver R, Kenna JG (2012) In vitro approach to assess the potential for risk of idiosyncratic adverse reactions caused by candidate drugs

This mechanistic distinction is the focus of ongoing preclinical research

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doi: 10.3389/fcimb.2016.00203 149 RaoSVSolumGNiederdorferBNorsettKGBjorkoyGThommesenL