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timsTOF HT Improves Protein Identification and Quantitative Reproducibility for Deep Unbiased Plasma Protein Biomarker Discovery

doi: 10.1056/NEJMoa1411892, 115 PlamboeckA.VeedfaldS.DeaconC

This tachyphylaxis occurs with continuous infusion of GLP-1 (154, 157), long acting GLP-1RAs (156), or tirzepatide (151)

One has to ask, why? Hashmi said

Why are patients with non-alcoholic fatty liver disease (NAFLD) suddenly being prescribed GLP-1 agonists and what are the effects on the liver

An apparent paradox is that whereas GLP-1 increases glucose-stimulated insulin secretion in the isolated pancreas fulfilling the definition of an incretin but it lowers insulin secretion in physiologically relevant conditions [6, 10, 18]