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As pointed out by De Berardinis et al., the changes in tumor ammonia metabolism between in vivo and in vitro experiments may differ significantly (255)

Similarly, other researchers have reported comparable treatment effects (Yen et al., 2021)

10.1021/acschemneuro.3c00531 [DOI] [PMC free article] [PubMed] [Google Scholar] Torres CM, Biran A, Burney MJ, Patel H, Henser-Brownhill T, Cohen AS, Li Y, Ben-Hamo R, Nye E, Spencer-Dene B, Chakravarty P, Efroni S, Matthews N, Misteli T, Meshorer E, Scaffidi P (2016) The linker histone H1.0 generates epigenetic and functional intratumor heterogeneity

(3) Metabolic shuttles and ETC nodes (mGPDH, complex I/II and PRODH): These enzymes can influence the CoQ redox state indirectly through substrate oxidation and electron flux

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