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Patients should always discuss supplement use with their healthcare provider to ensure that combinations are safe and appropriate for their specific medical conditions

Despite these promising findings, DSIP remains largely experimental, with formal clinical approval, standardized dosing, and long-term safety data still lacking

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Anticipate regular review of labs, symptoms, and hormonal equilibrium

In these studies, BAs (CDCA [42, 43], TUDCA [31, 44, 45], HCA [46], GUDCA [47]), FXR inhibitors (HS218[48], Gly-MCA [49, 50]), FXR agonists (Fexaramine [51, 52], GW4064 [53, 54]), FXR/TGR5 agonists (INT-767 [55]), TGR5 agonists (INT-777 [52], RO5527239 [52]), and clinical drugs (Colesevelam [56], Metformin [37, 57, 58], Acarbose [41], Obeticholic acid (OCA) [59,60,61]) all demonstrated hypoglycemic effects by activating different mechanisms