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Glucomannan is the only ingredient in this category with a conditional permitted health claim in the UK, and even this requires a specific dose alongside an energy-restricted diet

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It tells us something critical about how dose level influences digestive outcomes

This is called a burst, perforated or ruptured appendix

2791 kcal/kg comprising 19,3% proteins, 8,4% lipids, 72,4% digestible carbohydrates) ad libitum throughout the whole study from 6 weeks of age

Additional analyses included measurement of biomarkers such as follicle-stimulating hormone, bone-specific alkaline phosphatase, and creatinine phosphokinase