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Visible weight changes typically become apparent around weeks 8-12, when therapeutic doses kick in

We recheck labs and body composition at regular intervals

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While periodontitis supports the protection against local microbial attack, this inflammatory reaction can also damage the surrounding cells and connective tissue structures, including alveolar bone causing tooth loss (5, 6)

Monitor and document symptoms

[1] [4] The medication is administered as a once-weekly subcutaneous injection, with dosing typically initiated at 2.5 mg once weekly for 4 weeks, then increased by 2.5 mg every 4 weeks as needed and tolerated up to 15 mg