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The primary underlying pathomechanism is most likely a decreased hepatic GHR expression related to insulin deficiency, resulting in GH-resistance and impaired hepatic IGF-1 synthesis, which stimulates pituitary GH-secretion by a feedback mechanism [188, 189]

Okay, so they are trying to mimic what the body naturally does after eating

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Adiposity and cancer: meta-analysis, mechanisms, and future perspectives

Lu, S.-C