As a general guide, you may be suitable if you have: A body mass index (BMI) of 30 or above, or A BMI between 27 and 30 with at least one weight-related condition, such as high blood pressure, high cholesterol or type 2 diabetes
Optimized Intermittent Fasting (The 12-Hour Base) While intense 16:8 fasting is popular, 2026 protocols suggest a more flexible approach when combined with medication: The "Gentle Fast": A 12-hour overnight fast (e.g., 7 PM to 7 AM) provides metabolic benefits without the risk of undereating or hypoglycemia
Persistent Results: The drug has shown the potential for continuing weight loss beyond 52 weeks without a clear plateau
Sue Grigson, chair of neural and behavioral sciences at Penn State College of Medicine, who helped lead the opioid use study
While the control group also showed sustained ASMI decline, the magnitude was markedly smaller than in the treatment group (Figure 1)
Authors contributions Conceptualization and study design (TP, PP, ST), data acquisition (TP, ST), initial drafting of the manuscript (TP, ST), critical assessment of the manuscript and provision of intellectual input (TP, PP, ST)
