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Metformin, used for diabetes, can reduce B12 levels, which ironically prompts some to take extra supplements.
How frequent are serious systemic reactions in routine practice
What Factors Affect How Quickly You See Results
In most food sources, B12 is bound to a protein molecule released by the metabolic activity of hydrochloric acid and other enzymes in the stomach
Maintenance Phase: Many users transition to maintenance dosing during this period, having achieved significant metabolic improvements