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Through targeting long non-coding RNA [74] or the promoter region of the SCN1A gene with CRISPRa [75], the studies successfully increased SCN1A expression and restored dysfunctional neuron excitability and seizure phenotypes

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[DOI] [PMC free article] [PubMed] [Google Scholar] 57.Lee YT, Chen YL, Wu YH, Chen IS, Chang HS, Wang YH, et al

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