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doi: 10.21037/tau.2019.11.30 94 BerlangaJCibrianDGuevaraLDominguezHAlbaJSSeralenaAet al

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It is also increasingly clear that addictive drugs (Koob, 1992) can hijack the reward system, a system originally evolved to motivate the drive for natural rewards

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[5] However, it is crucial to note that this represents a physiological adaptation to reduced mechanical stress rather than a direct toxic effect on bone tissue