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The improvement effect of semaglutide on obese mice is partially driven by changes in serum metabolism and gut microbiota, as confirmed by fecal transplant experiments in this study

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N Engl J Med 381(7):637646 Tornehave D, Kristensen P, Rmer J, Knudsen LB, Heller RS (2008) Expression of the GLP-1 receptor in mouse, rat, and human pancreas

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