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Weak antioxidant defenses make the heart a target for damage in copper-deficient rats

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Spermidine and spermine are catabolized by spermidine/spermine N 1 -acetyltransferase 1 (also known as diamine acetyltransferase 1) encoded by the SAT1 gene (also identified as SSAT)

Elevated oxidative stress, alongside metabolic dysregulation and inflammation will disrupt energy metabolism, potentially leading to fatigue and other debilitating symptoms characteristic of these conditions