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In cardiac muscle, NAD+ supports mitochondrial function and energy production while protecting against ischemic injury and age-related cardiac dysfunction

This also raises an unresolved question as to whether GSH efflux serves primarily as a permissive biochemical event or represents an actively regulated signaling step in apoptotic commitment

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10 , 826837 (2010) Nimmerjahn, A., Kirchhoff, F

[1] Acute kidney injury has been reported, particularly in patients experiencing severe gastrointestinal adverse reactions with volume depletion