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Further, dihexa and Nle1-AngIV induce hippocampal spinogenesis and synaptogenesis similar to HGF itself

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GHK-Cu vs DHK-Cu vs AHK-Cu All three peptides possess the histidyl-lysine motif, which serves as the copper-binding core

Moreover, IHC analysis of filaggrin and loricrin, key proteins involved in epidermal barrier function, revealed that glutathione amino acid precursors treatment enhanced their levels in UVB-exposed skin, supporting the protective effects of glutathione amino acid precursors on barrier function

Furthermore, p-JNK leads to the activation of Bax and translocation to mitochondria to trigger the mitochondrial permeability transition (MPT) pore formation, along with collapsed ATP depletion and membrane potential, eventually causing DNA fragmentation and necrosis (Bajt et al., 2006

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