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This migration activates Ngn3-positive endocrine progenitor cells, facilitating -cell regeneration, effectively reversing hyperglycemia, increasing insulin secretion, and restoring islet architecture

The enhanced weight loss observed in response to GLP-1MK-801 coincided with a more pronounced decrease in food intake within the first 48 h after the infusion relative to semaglutide-treated mice (Fig

BH4 serves as a coenzyme for critical neurotransmitter (e.g., dopamine) and nitric oxide synthesis pathways (58) and coregulates ferroptosis through two mechanisms

The free thiol oxidises to the disulfide GSSG on air exposure, and the oxidation rate rises with pH as thiolate character increases

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