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White blood cells from patients with COVID-19 activate brain endothelial cells Given the prevalence of circulating markers indicative of BBB dysfunction and immune cell activation, we examined gene expression changes in peripheral blood mononuclear cells (PBMCs) isolated from unaffected ( n = 7), recovered ( n = 5) and patients with long COVID with ( n = 6) or without ( n = 5) brain fog using RNA sequencing (RNA-seq)

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This secretory phenotype is known as the senescence-associated secretory phenotype (SASP)

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