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Complementary mechanistic evidence has emerged from neurodegenerative research: In Parkinson's disease (PD) models characterized by substantia nigra dopaminergic neuron loss, Trx1 exerts ferroptosis inhibition via the modulation of GPX4 activity and glutathione (GSH) (65)

GHK-Cu (Glycyl-L-histidyl-L-lysine copper) is a small tripeptide found naturally in human plasma, saliva, and urine

Glucagon-like peptide-1 inhibits adipose tissue macrophage infiltration and inflammation in an obese mouse model of diabetes

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Although Pol- has relatively low affinity for these analogues (100), their incorporation causes premature chain termination during mtDNA replication, leading to mtDNA depletion, reduced expression of -encoded OXPHOS subunits, and ultimately impaired ETC function and ATP production (101103)