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In addition, selection in the presence of serum, halides and thiols could help to enrich variants that are tolerant to those species

However, it was not recognized at the time that evidence for the protein binding hypothesis was obtained in animals on a normal diet whereas the LPO hypothesis was derived from animals fed a vitamin E-deficient diet high in polyunsaturated fatty acids (PUFAs), i.e., in animals highly susceptibility to LPO [61]

While your cells naturally make glutathione, the amount produced could drop under certain conditions

Over time, factors like pollution, stress, UV exposure, and aging can deplete natural glutathione levels, leading to hyperpigmentation, dullness, and uneven skin tone

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