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Some studies suggest that priming peripheral blood mononuclear cells (PBMCs) with urate enhances the release of interleukin-1 (IL-1) in response to lipopolysaccharide (LPS), indicating a potential pro-inflammatory effect

Thus, maintaining adequate levels of glutathione is essential for protecting mitochondria from oxidative damage

Its formulation typically includes

The reasons for discrepancy among these studies are unclear

Overexpression of CBS also has the downstream effect of increasing cysteine availability and the potential for a functional folic acid deficiency known as the folate trap in DS individuals (Pogribna et al , 2001)

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