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64 However, persistent activation during reperfusion exacerbates cell death, as AMPK promotes autophagy, whereas RHEB/mTORC1 suppresses it, aggravating myocardial injury

That is exactly what Gupta et al

Emerging consumer data show that individuals on GLP-1 therapies reduce their caloric intake significantly, often by 20% or more, and cut grocery spending by roughly 5% within months of starting treatment