Am J Physiol Endocrinol Metab (2007) 293:E74353.10.1152/ajpendo.00159.2007 44 PilichiewiczANPapadopoulosPBrennanIMLittleTJMeyerJHWishartJMet alLoad-dependent effects of duodenal lipid on antropyloroduodenal motility, plasma CCK and PYY, and energy intake in healthy men
Many of them did not result in meaningful weight loss and/or had many bad side effects, which is why it is not surprising that most group health plan sponsors chose not to cover those weight-loss medications
PMID 1971748
In 1997, American Home Products, which later became Wyeth, took its fen-phen product off the market
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Based on the findings in that paper, I developed a clinical research program and was lucky to win a 5-year grant from the Novo Nordisk Foundation that allowed us to study the relationship between bile and GLP-1 in humans
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