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[DOI] [PMC free article] [PubMed] [Google Scholar] 181

The Impact of GLP-1 on the Balance between Bone Formation and Bone Resorption Normal bone metabolism in humans involves both bone formation and bone resorption in a balanced state of equilibrium

Short term use may provide value during periods of increased demand, while ongoing protocols require thoughtful budgeting

Inflammation Reduction Lowers swelling and discomfort from chronic conditions like arthritis

Li 2012

In summary: Evaluating SMM loss plausibly due to GLP-1 medications compared to weight loss through other interventions (without GLP-1 medications), we find a dearth of evidence of disproportionate muscle mass loss