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The HIF-1 pathway is frequently activated in hypoxic inflammatory sites (RA joint, IBD gut), stabilizing Th17 responses and antagonizing Treg stability

The stratum corneum showed a 2-hour lag, while the full epidermis required up to 7 hours for significant penetration

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This observation suggests that the TCA cycle cannot meet energy demands under stress, forcing cells to rely primarily on glycolysis for energy production (74)

106,107 Based on the purpose of improving the efficacy of ASNase in hematological malignancies, expanding the use of ASNase and reducing side effects, a new generation of ASNase is being developed (Tables 1, 2)

However, many people have no side effects or only have minor side effects