glp-1 vs gip Comparison between RA and the GLP-1/GIP dual agonist 𝗧𝗵𝗲 𝗘𝗳𝗳𝗲𝗰𝘁 𝗼𝗳 𝗚𝗟𝗣-𝟭 𝗥𝗲𝗰𝗲𝗽𝘁𝗼𝗿

Epidemiol Rev 36 , 7182, (2014)

doi: 10.1021/jf500803c 128

Studies have shown that postprandial levels of endogenous GLP-1 after bariatric surgery can be 10 to 20 times higher compared with before surgery. In a retrospective study, Gazda and colleagues analyzed data from 207 adults treated for weight regain after bariatric surgery at an academic center from January 2014 to November 2019

The safety profile was consistent with GLP-1 receptor agonists, primarily featuring transient, mild-to-moderate gastrointestinal adverse events (e.g., nausea, 55%), with low discontinuation rates (6-8.4%)

Sometimes doctors prescribe smaller amounts, but some GLP-1 users decide to microdose on their own

These trials are meticulously designed, randomized, placebo-controlled studies aimed at determine how antidiabetic medications influence cardiovascular outcomes, particularly in high-risk T2D patients (35)