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Although NRF2 does not directly regulate serine synthesizing enzyme genes, ATF4, a key regulator of serine synthesis, was shown to be activated by NRF2
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Dried blood spot testing has achieved detection limits of 2.5 ng/mL
There are documented case reports of extreme appetite suppression and psychiatric complications requiring GLP-1 discontinuation in people with restrictive eating patterns ( Leziak et al., J Psychiatric Research, 2026 )
