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Clinical trials have demonstrated that weight reduction occurs gradually over 12 to 18 months, with most patients reaching maximum effect within this timeframe

doi: 10.1016/j.ejps.2012.07.003 3 AkimotoH.TezukaK.NishidaY.NakayamaT.TakahashiY.AsaiS

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Interestingly, FGF21, SREBP-1c, and FAS mRNA in the liver tissues of the model group of mice and protein expression was increased compared with the control group, while liver kinase B1 (LKB1) mRNA expression was reduced

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