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Under hypoxia or mitochondrial dysfunction, -KG can be converted to citrate by Isocitrate dehydrogenase (IDH 2) catalyzed carboxylation reaction, which is used for the synthesis of amino acids and fatty acids and the production of reducing agent NADPH

In small amounts, free radicals are normal and even necessary for certain cellular signals

Are there any known contraindications

On the other hand, transcripts from these genes were down-regulated in two susceptible cultivars (compatible interaction)